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The inflammatory response leads to increased permeability of the endothelial lining, influx of blood leukocytes into the interstitial space, an oxidative burst, and the release of cytokines

Pre-existing neutralizing antibodies to AAVrh.10 appear to be less prevalent than those to AAV2 or AAV8, supporting the suitability of AAVrh.10 for liver-directed applications (69)